Undifferentiated Pleomorphic Sarcoma

Definition

 

Previously Malignant Fibrous Histiocytoma (MFH)

 

? Combined with myxofibrosarcoma as genomically indistinguishable

 

Cell / tissue of origin unknown

 

MRI 

 

MFH Thigh Coronal MRIMFH Thigh MRI Axial

 

Pleomorphic sarcoma 1Pleomorphic sarcoma 2Pleomorphic sarcoma 3

 

Histology

 

Diagnosis of exclusion

 

Management

 

Wide resection + radiotherapy

 

Role of chemotherapy unclear

 

Prognosis

 

Zhang et al Zhonghua Zhong Liu Za Zhi 2019

- 131 cases of undifferentiated pleomorphic sarcoma

- 5 year survival 72%