Irradiate a slice of tissue from multiple angles
Measure the output from different sides
Tissues have different densities
- with denser tissue fewer x-rays reach the detectors
Bone 2000
ST 40
Water 0
Fat -100
Air -1000
Malignant Fibrous Histiocytoma
Characterised by heterogenous population of pleomorphic spindle cells
- organised in a characteristic storiform or "starry night" pattern
Cell of origin unknown
- primitive mesenchymal cell
- allowing both features of a macrophage (hence histiocyte)
- and collagen producing cell (hence fibroblast)