sarcoma

Paget's Disease

Chronic, non metabolic bone disorder

Characterised by increased bone resorption, bone formation and remodelling

Rare < 40

1 – 3 % population over 60

M > F

Unknown

Paramyxovirus implicated

- measles

- RSV

- canine distemper virus

Electron Microscope

Malignant Fibrous Histiocytoma

Characterised by heterogenous population of pleomorphic spindle cells

- organised in a characteristic storiform or "starry night" pattern

Cell of origin unknown

- primitive mesenchymal cell

- allowing both features of a macrophage (hence histiocyte)

- and collagen producing cell (hence fibroblast)