Hyperbaric Oxygen

Mechanism

 

Elevated tissue oxygen tensions

 

Assists Neutrophils

- In hypoxic tissue 

- require PO2> 40mmHg (5.3Kpa) for bacterial killing

 

Bacteriocidal to Anaerobes

 

Potentiates effects of Antibiotics

- Aminoglycosides

- Sulphonamides

- Trimethoprim

- Fluoroquinolones

- and Vancomycin in hypoxic tissues

 

Indications

 

Anaerobic fasciitis / Gangrene

- Reduce mortality when added to surgical debridement and Antibiotics

 

Complex diabetic foot

- reduces amputation rates in complex diabetic foot lesions including osteomyelitis

 

Crush injury

- shown to improve rate of healing and reduced re-operation in crush injury

 

Chronic Refractory Osteomyelitis

 

Technique

 

Usually use 2-2.8 Atmospheres

 

Need 6/52 to gain vascular ingrowth