Hepatits C
Epidemiology
- 0.5% blood donors positive
NHx
- 20% carriers get cirrhosis at 20ys
- 5% get Hepatocellular Ca
Transmission
- Mainly IV Drug abuse
- Little evidence for sex spread
Needle-stick
- risk seroconversion is 3%
- only if patient HCV RNA +
- 30% of patients clear the HCV / will remain Antibody positive
Hepatitis B
Epidemiology
Australia has a mosaic incidence due to multicultural population
- Asia 10%
- Southern Europe 10%
- Northern Europe 0.1%
Transmission
- Extremely infectious
- IV Drug abuse
- sex
- Neonatal infection
Diagnosis
HBsAg +
- Currently infected & infectious
- Acute & Chronic Hepatitis
HBeAg
- Older marker of infectivity
Anti-HBc
- Antibody to core antigen
- Post infected immunity
Anti-HBs
- Vaccinated
- Post-Infection Immunity
HBVDNA
- Direct marker infectivity
- Acute & Chronic Hepatitis