Denosumab

Mirels Prediction system for Pathological Fracture

Clin Orthop 1989 

- 38 patients treated with DXRT without surgery 

- most breast cancer

- developed scoring system

- predicts post DXRT fracture risk in preDXRT long bones

- risk of fracture within 6 months 

- irradiated without fixation

Four risk factors

Definition

Benign lesion with a wide spectrum of behavior characterized by stromal cells and giant cells

Epidemiology

Common

- 20% of benign tumours

More common females

- F:M = 1.5:1

- most tumours M>F

Usually patient in 20's

- usually after skeletal maturity

- 3% < epiphyseal closure