etiology

DIC

Definition

 

Disseminated Intravascular Coagulation

 

Pathology

 

Results from excessive activation of either extrinsic or intrinsic coagulation pathway

- multiple small clots 

- consumptive coagulopathy

 

1.  Excessive Extrinsic Activation

 

Secondary to extensive cellular destruction

- thromboplastins +++ released into circulation

CRPS

Definition

 

Chronic Regional Pain Syndrome

 

CRPS 1

 

Sympathetically mediated pain syndrome

- excessive or exaggerated response of extremity to injury, surgery or disease

 

Manifested by

- intense or unduly prolonged pain

- vasomotor disturbances

- trophic changes

- delayed functional recovery

 

CRPS 2

 

Von Willebrand's Disease

Incidence

 

Most common of the bleeding disorders

- 1:100

 

Function

 

vWF            

- needed for platelet adhesion and platelet-platelet interactions

- also carrier for factor VIII / protects it from rapid breakdown

 

Aetiology

 

Gene on chromosome 12

1.  Reduced production VWF