Bone

Definition

Chronic, non metabolic bone disorder

Characterised by increased bone resorption, bone formation and remodelling

Epidemiology

Rare < 40

1 – 3 % population over 60

M > F

Aetiology

Unknown

Paramyxovirus implicated

- measles

- RSV

- canine distemper virus

Electron Microscope

1.  Pattern of bone destruction

Geographic

Least aggressive

- usually indicative of slow growing lesion

- usually seen in benign tumours

- may be myeloma / mets / OM

Narrow transition from normal to abnormal bone

- Margin of the lesion is well defined

- margin is easily separated from surrounding bone

- margin may be smooth / irregular, sclerotic / non  sclerotic