Abnormal Physis

Trauma

- growth arrest line

 

Infection

 

Tumor

- leukemia                                   

- neuroblastoma

 

Metabolic

- rickets  (calcifiable matrix is formed, but matrix doesn’t calcify due to lack of available mineral)

- scurvy (metaphyseal disarray /  calcified cartilage persists into metaphysis /  very little osteoid)

 

Drugs & toxins

- lead

- pamidronate

 

Dysplasia

- achondroplasia

- OI (2o spongiosa abnormal development)