platelets

Blood Products

Goal

 

Ultimate goal of blood management is to AVOID allogenic blood transfusion

 

Problems

 

Increased infection rate

- demonstrated in THR

- decreased killer T cells

Increased risk disease transmission

Increased risk transfusion reaction

Increased post-op fever and antibiotic requirements

Increased cost

Background

Aim of Coagulation

 

To produce sufficient thrombin to rapidly convert soluble fibrinogen into insoluble mass of fibrin

 

Coagulation cascade must be localised & limited to site of tissue injury

 

Three phases

 

1.  Immediate Control of Blood Loss

 

Vascular Phase

- damage to blood vessel triggers reflex vasoconstriction

 

Platelet phase