cryoprecipitate

Goal

Ultimate goal of blood management is to AVOID allogenic blood transfusion

Problems

Increased infection rate

- demonstrated in THR

- decreased killer T cells

Increased risk disease transmission

Increased risk transfusion reaction

Increased post-op fever and antibiotic requirements

Increased cost

Incidence

Most common of the bleeding disorders

- 1:100

Function

vWF            

- needed for platelet adhesion and platelet-platelet interactions

- also carrier for factor VIII / protects it from rapid breakdown

Aetiology

Gene on chromosome 12

1.  Reduced production VWF