complement

Systemic Lupus Erythematosus (SLE)

Systemic Connective Tissue Disease

Chronic inflammatory disease resulting from abnormal immunoregulation

Unknown

Thought similar to RA

1. Genetic factors

2. Environmental factors

Young females

F:M 9:1

Peak 35 years old

Response of body to injury

Vascular Phase

- redness, heat & swelling

- transient vasoconstriction after injury

- then vasodilatation of arterioles

- increased permeability followed by plasma exuded into extravascular space

Cellular Phase

- leukocytes adhere to endothelium

- margination - migrate into extravascular space